Ep. 146: The Brotherhood of the Screaming Abyss & Psychedelic Biochemistry (feat. Dennis McKenna)

Today we are honored by the presence of the legendary Dr. Dennis McKenna. Dr. McKenna has conducted research in ethnopharmacology for over 40 years.  He is a founding board member of the Heffter Research Institute, and was a key investigator on the Hoasca Project, the first biomedical investigation of ayahuasca.  He is the younger brother of Terence McKenna.  From 2000 to 2017, he taught courses on Ethnopharmacology and Plants in Human affairs as an adjunct Assistant Professor in the Center for Spirituality and Healing at the University of Minnesota. In 2018, Dr. McKenna conceived the McKenna Academy of Natural Philosophy to explore modern and traditional practices, ideas and technologies that foster the understanding of nature, consciousness, the cosmos and their interweavings with humanity. The Academy’s mission is to be a catalyst for the transformation of global consciousness, through educational experiences that interweave our collective intelligence, science, and ancestral wisdom.   


  • The Brotherhood of the Screaming Abyss   
  • The Experiment at La Chorrera   
  • Ethnopharmacology   
  • Tryptophan, Tryptamines & 5HT2A Receptors
  • Psychedelic Biochemistry   
  • Messenger Molecules & Signal Transduction   
  • Psychedelic Communications
  • Neural Gating & The Reality Hallucination   
  • Future of Psychedelics in Modern, Western Culture   
  • Psychedelics Sourced from South America – Short-Term Extraction, Long-Term Symbiosis?   
  • Nature Wave Zero   
  • Humans as an Endangered Species   
  • Undiscovered Psychedelic Compounds   
  • The McKenna Academy   


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